Seasonal and environmental allergy symptoms

Sabalia® helps fight seasonal allergies (hay fever, pollen) and environmental allergies (dust, mould, pet hair).
Sabalia® tablets are antihistamine- and pseudoephedrine-free.

Sabalia® is easy to take without water and does not cause any drowsiness. Start at the first signs of allergy symptoms (runny nose, sneezing, itchy/watery eyes, scratchy throat) for maximum relief.

Manifestations: Allergic rhinitis is seasonal or perennial itching, sneezing, rhinorrhea, nasal congestion, and sometimes conjunctivitis, caused by exposure to pollens or other allergens. Patients have itching in the nose, eyes, or mouth, sneezing, rhinorrhea, and nasal and sinus obstruction.

Contains:

Rheum is a homeopathic remedy used for the natural treatment of:

• colicky babies who are always screaming and crying
• vomiting that leaves a sour taste in the mouth
• diarrhea
• nausea and vomiting in pregnancy
• difficult teething in babies

From Boericke:

 (Rhubarb) Of frequent use in children with sour diarrhoea; difficult dentition. WHOLE CHILD SMELLS SOUR.

Mind
Impatient and vehement; desires many things and cries. (CINA.)

Head
Sweat on hairy scalp; constant and profuse. COOL SWEAT ON THE FACE, ESPECIALLY ABOUT MOUTH AND NOSE.

Mouth
Much saliva. Sensation of coolness in teeth. Difficult teething; restless and irritable. Breath smells sour. (CHAM.)

Stomach
Desire for various kinds of food, but soon tires of all. Throbbing in pit. Feels full.

Abdomen
Colicky pain about navel. Colic when uncovering. Wind seems to rise up to chest.

Rectum
Before stool, unsuccessful urging to urinate. STOOLS SMELL SOUR, pasty, with shivering and tenesmus, and burning in anus. Sour diarrhoea during dentition. Colicky, even ineffectual urging to evacuate altered faecal stools.

Modalities
WORSE, uncovering, after eating, moving about.

Relationship
Compare: MAG. PHOS.; HEP.; POD.; CHAM.; IPEC. Antidotes: CAMPH.; CHAM. Complementary: MAG. CARB.

Dose
Third to sixth potency.

Oak - Buds

Indications: Stimulate adreno-cortical gland

Quercus pedunculata (robur) is a general tonic for the body. It is specifically an adrenal and sexual tonic and can stimulate testosterone production and stimulates the pituitary gland. It is an antiviral that can be used to treat recurring herpes. It also has healing properties assocated with the mouth and can heal gums. 

Gemmotherapy remedies are very close to herbal, so there can be counter-indications. Please consult your health care practitioner before using any of the gemmotherapy remedies, or ask one of our skilled homeopaths for advice!

Pulsatilla is a homeopathic remedy used for the natural treatment of :

• depression
• changeable moods
• PMS
• period pain
• menstrual pain/cramps
• headaches
• colds and flus
• conjunctivitis
• pink eye
• sinusitis
• chicken pox
• anxiety
• ear infections
• otitis media
• labour pains
• styes 

From Boericke:

(Wind Flower) The weather-cock among remedies. The disposition and mental state are the chief guiding symptoms to the selection of Pulsatilla. It is pre-eminently a female remedy, especially for mild, gentle, yielding disposition. Sad, crying readily; weeps when talking; CHANGEABLE, contradictory. THE PATIENT SEEKS THE OPEN AIR; ALWAYS FEELS BETTER THERE, even though he is chilly. Mucous membranes are all affected. DISCHARGES THICK, BLAND, AND YELLOWISH-GREEN. Often indicated after abuse of Iron tonics, and after badly-managed measles. SYMPTOMS EVER CHANGING. THIRSTLESS, PEEVISH, AND CHILLY. When first serious impairment of health is referred to age of puberty. Great sensitiveness. Wants the head high. Feels uncomfortable with only one pillow. Lies with hands above head.

Mind
Weeps easily. Timid, irresolute. Fears in evening to be alone, dark, ghosts. Likes sympathy. Children like fuss and caresses. Easily discouraged. Morbid dread of the opposite sex. Religious melancholy. Given to extremes of pleasure and pain. Highly emotional. Mentally, an April day.

Head
Wandering stitches about head; pains extend to face and teeth; vertigo; better in open air. Frontal and supraorbital pains. Neuralgic pains, commencing in RIGHT TEMPORAL region, WITH SCALDING LACHRYMATION OF AFFECTED SIDE. HEADACHE FROM OVERWORK. Pressure on vertex.

Ears
Sensation as if something were being forced outward. Hearing difficult, as if the ear were stuffed. Otorrhoea. Thick, bland discharge; offensive odor. External ear swollen and red. Catarrhal otitis. Otalgia, worse at night. Diminishes acuteness of hearing.

Eyes
THICK, PROFUSE, YELLOW, BLAND DISCHARGES. Itching and burning in eyes. Profuse lachrymation and secretion of mucus. LIDS INFLAMED, AGGLUTINATED. STYES. Veins of fundus oculi greatly enlarged. Ophthalmia neonatorum. Subacute conjunctivitis, with dyspepsia; worse, in warm room.

Nose
Coryza; stoppage of right nostril, pressing pain at root of nose. Loss of smell. Large green fetid scales in nose. Stoppage in evening. Yellow mucus; abundant in morning. Bad smells, as of old catarrh. Nasal bones sore.

Face
Right-sided neuralgia, with profuse lachrymation. Swelling of lower lip, which is cracked in middle. Prosopalgia towards evening till midnight; chilly, with pain.

Mouth
Greasy taste. DRY MOUTH, WITHOUT THIRST; wants it washed frequently. Frequently licks the dry lips. CRACK IN MIDDLE OF LOWER LIP. YELLOW OR WHITE TONGUE, COVERED WITH A TENACIOUS MUCUS. Toothache; relieved by holding cold water in mouth. (COFF.) Offensive odor from mouth. (MERC; AUR.) Food, especially bread, tastes bitter. Much SWEET saliva. ALTERATIONS OF TASTE, bitter, bilious, greasy, salty, FOUL. Loss of taste. Desire for tonics.

Stomach
AVERSE TO FAT FOOD, WARM FOOD, AND DRINK. Eructations; TASTE OF FOOD REMAINS A LONG TIME; after ices, fruits, pasty. BITTER TASTE, diminished taste of all food. Pain as from subcutaneous ulceration. FLATULENCE. Dislikes butter. (SANG). Heartburn. Dyspepsia, with great tightness after a meal; must loosen clothing. THIRSTLESSNESS, with nearly all complaints. Vomiting of food eaten long before. Pain in stomach an hour after eating. (NUX.) Weight as from a stone, especially in morning on awakening. Gnawing, hungry feeling. (ABIES C.) Perceptible pulsation in pit of stomach. (ASAF.) All-gone sensation, especially in tea drinkers. Waterbrash, with foul taste in the morning.

Abdomen
Painful, distended; loud rumbling. Pressure as from a stone. Colic, with chilliness in evening.

Stool
Rumbling, watery; worse, night. NO TWO STOOLS ALIKE. After fruit. (Ars.; CHIN.) Blind haemorrhoids, with itching and sticking pains. Dysentery; mucus and blood, with chilliness. (MERC; RHEUM.) TWO OR THREE NORMAL STOOLS DAILY. Urine. Increased desire; WORSE WHEN LYING DOWN. Burning in orifice of urethra during and after micturition. Involuntary micturition at night, while coughing or passing flatus. After urinating, spasmodic pain in bladder.

Female
Amenorrhoea. (CIMICIF.; SENEC; POLYGON.) Suppressed menses from wet feet, nervous debility, or chlorosis. Tardy menses. Too late, scanty, thick, dark, CLOTTED, CHANGEABLE, INTERMITTENT. Chilliness, nausea, downward pressure, painful, flow intermits. Leucorrhoea acrid, burning, creamy. Pain in back; tired feeling. Diarrhoea during or after menses.

Male
Orchitis; pain from abdomen to testicles. Thick, yellow discharge from urethra; late stage of gonorrhoea. Stricture; urine passed only in drops, and stream interrupted. (CLEMAT.) ACUTE PROSTATITIS. Pain and tenesmus in urinating, WORSE LYING ON BACK.

Respiratory
Capricious hoarseness; comes and goes. DRY COUGH IN EVENING AND AT NIGHT; MUST SIT UP IN BED TO GET RELIEF; AND LOOSE COUGH IN THE MORNING, with copious mucous expectoration. PRESSURE UPON THE CHEST AND SORENESS. Great soreness of episgastrium. Urine emitted with cough. (CAUST.) Pain as from ulcer in middle of chest. Expectoration bland, thick, bitter, greenish. Short breath, anxiety, and palpitation when lying on left side. (PHOS.) Smothering sensation on lying down.

Sleep
WIDE AWAKE IN THE EVENING; first sleep restless. Wakes languid, unrefreshed. Irresistible sleepiness in afternoon. Sleeps with hands over head.

Back
Shooting pain in the nape and back, between shoulders; in sacrum after sitting.

Extremities
Drawing, tensive pain in thighs and legs, with restlessness, sleeplessness and CHILLINESS. PAIN IN LIMBS, SHIFTING RAPIDLY; tensive pain, LETTING UP WITH A SNAP. Numbness around elbow. Hip-joint painful. Knees swollen, with tearing, drawing pains. Boring pain in heels toward evening; SUFFERING WORSE FROM LETTING THE AFFECTED LIMB HANG DOWN. (VIPERA.) Veins in forearms and hands swollen. Feet red, inflamed, swollen. Legs feel heavy and weary.

Skin
Urticaria, after rich food, with diarrhoea, from delayed menses, worse undressing. MEASLES. Acne at puberty. Varicose veins.

Fever
CHILLINESS, even in warm room, WITHOUT THIRST. Chilly with pains, in spots, worse evening. Chill about 4 p.m. Intolerable burning heat at night, with distended veins; heat in parts of body, coldness in other. One-sided sweat; pains during sweat. EXTERNAL HEAT IS INTOLERABLE, VEINS ARE DISTENDED. During apyrexia, headache, diarrhoea, loss of appetite, nausea.

Modalities
WORSE, from heat, rich fat food, after eating, towards evening, warm room, lying on left or on painless side, when allowing feet to hang down. BETTER, open air, motion, cold applications, cold food and drinks, though not thirsty.

Relationship
PENTHORUM, often indicated after Pulsatilla in later colds. IONESIA ASOCA-Saraca indica-(AMENORRHEA, Menorrhagia-acts powerfully on female organs. Abdominal pain). ATRIPLEZ (Uterine symptoms, amenorrhoea; hysteria, coldness between shoulders, dislike of warm food, craves strange foods, palpitation, sleeplessness). PULSATILLA NUTTALIANA, identical effects. Compare: CYCLAMEN; KALI BICH.; KALI SULPH.; SULPHUR. PIMENTA-Allspice-(one-sided neuralgias, parts of body hot and cold). ANAGYRIS (headache, amenorrhoea). Complementary: COFFEA; CHAMOM.; NUX.

Dose
Third to thirtieth attenuation.

Psorinum is a homeopathic remedy used for the natural treatment of:

• ezcema
• psoriasis
• recurrent ear infections
• recurrent eye infections
• sinusitis
• allergies
• hayfever
• allergic rhinitis
• bedwetting
• headaches
• skin conditions 

From Boericke:

(Scabies Vesicle) The therapeutic field of this remedy is found in so-called psoric manifestations. Psorinum is a cold medicine; wants the head kept warm, WANTS WARM CLOTHING even in summer. EXTREME SENSITIVENESS TO COLD. DEBILITY, independent of any organic disease, especially the weakness remaining after acute disease. LACK OF REACTION, i. e., phagocytes defective; when well-chosen remedies fail to act. Scrofulous patients. Secretions HAVE A FILTHY SMELL. Profuse sweating. Cardiac weakness. Skin symptoms very prominent. Often gives immunity from cold-catching. Easy perspiration when walking. Syphilis, inherited and tertiary. OFFENSIVE DISCHARGES.

Mind
Hopeless; despairs of recovery. MELANCHOLY, deep and persistent; religious. Suicidal tendency.

Head
Awakens at night with pain as from blow on head. Chronic headaches; hungry during attacks; with vertigo. Hammering pain; brain feels too large; worse, change of weather. Dull, pressive pain in occiput. Humid eruption on scalp; hair matted. Hair dry.

Eyes
Agglutinated. Blepharitis. CHRONIC OPHTHALMIA, THAT CONSTANTLY RECURS. Edges of lids red. Secretion acrid.

Mouth
Obstinate rhagades at corners. Tongue, gums ulcerated; tough mucus of foul taste adheres to soft palate.

Nose
Dry, coryza, with stoppage of nose. Chronic catarrh; dropping from posterior nares. Acne rosacea.

Ears
Raw, red, OOZING SCABS AROUND EARS. Sore pain behind ears. Herpes from temples over ears to cheeks. OFFENSIVE DISCHARGE FROM ECZEMA AROUND EARS. INTOLERABLE ITCHING. Chronic otorrhoea. MOST FETID PUS FROM EARS, brownish, offensive.

Face
Swelling of upper lip. Pale, delicate. HUMID ERUPTION ON FACE. Sickly. Throat. Tonsils greatly swollen; painful swallowing, with pain in ears. Profuse, offensive saliva; tough mucus in throat. Recurring quinsy. ERADICATES TENDENCY TO QUINSY. Hawking up of cheesy, pea-like balls of disgusting smell and taste. (AGAR.)

Stomach
Eructations like bad eggs. VERY HUNGRY ALWAYS; MUST HAVE SOMETHING TO EAT IN THE MIDDLE OF THE NIGHT. Nausea; vomiting of pregnancy. Pain in abdomen after eating.

Stool
Mucous, BLOODY, EXCESSIVELY FETID, DARK FLUID. Hard, difficult stool, with blood from rectum and burning piles. CONSTIPATION OF INFANTS, in pale, sickly scrofulous children.

Female
LEUCORRHAZA fetid, lumpy, with much backache and DEBILITY. Mammae swollen and painful. Pimples oozing an acrid fluid that burns and excoriates the glands.

Respiratory
Asthma, with dyspnoea; worse, sitting up; better, lying down and keeping arms spread wide apart. Dry, hard cough, with great weakness in chest. FEELING OF ULCERATION UNDER STERNUM. Pain in chest; better, lying down. Cough returns every winter, from suppressed eruption. HAY-FEVER returning irregularly every year.

Extremities
Weakness of joints, as if they would not hold together. ERUPTION AROUND FINGER-NAILS. Fetid foot-sweats.

Skin
Dirty, dingy look. Dry, lustreless, rough hair. INTOLERABLE ITCHING. Herpetic eruptions, especially on scalp and bends of joints with itching; worse, from warmth of bed. Enlarged glands. Sebaceous glands secrete excessively; oily skin. Indolent ulcers, slow to heal. Eczema behind ears. Crusty eruptions all over. Urticaria after every exertion. Pustules near finger-nails.

Fever
Profuse, offensive perspiration; night-sweats.

Sleep
Sleepless from intolerable itching. Easily startled.

Modalities
WORSE, coffee; Psorinum patient does not improve while using coffee. WORSE, changes of weather, in hot sunshine, from cold. DREAD OF LEAST COLD AIR OR DRAFT. BETTER, heat, warm clothing, even in summer.

Relationship
Complementary: SULPHUR. Compare: PEDICULUS-Head-louse-(psoric manifestations in children. Eruption on dorsum of hands, feet, neck. Prurigo; pellagra. Unusual aptitude for study and work). PEDICULUS (Cooties) transmit typhus and trench fever.) In lack of reaction compare CALCAREA and NATRUM ARS. GAERTNER. (Pessimistic, lack of confidence, subjective troublesome eye symptoms, fear of heights. Urticaria. Use 30th and 200th. (Wheeler.)

Dose
Two hundredth and higher potencies. Should not be repeated too often. PSORINUMrequires something like 9 days before it manifests its action, and even a single dose may elicit other symptoms lasting for weeks. (Aegedi.)

Sweet Almond - Buds (also available: branch bark)

Indications: Hypertension

Black poplar - buds

Indications: Arterial antispasmodic

 Podophyllum is a homeopathic remedy used for the natural treatment of:

• food poisoing
• diarrhea that is explosive and with lots of gas
• weakness after diarrhea
• ulcerative colitis
• cronh's disease
• irritable bowel syndrome
• vomiting
• involuntary stools
• prolapse of rectum

 From Boericke:

(May-apple) Is especially adapted to persons of bilious temperament. It affects chiefly the DUODENUM, small intestines, liver, and RECTUM. The Podophyllum disease is a gastro-enteritis with colicky pain and bilious vomiting. Stool is watery with jelly-like mucus, painless, PROFUSE. Gushing and offensive. Many troubles during pregnancy; pendulous abdomen after confinement; prolapsus uteri; painless cholera morbus. Torpidity of the liver; portal engorgement with a tendency to hemorrhoids, hypogastric pain, fullness of superficial veins, jaundice.

Mind
Loquacity and delirium from eating acid fruits. Depression of spirits.

Head
Vertigo, with tendency to fall forward. Headache, dull pressure, worse morning, with heated face and bitter taste; ALTERNATING WITH DIARRHEA. ROLLING OF HEAD FROM SIDE TO SIDE, with moaning and vomiting and eyelids half closed. Child perspires on head during sleep.

Mouth
Grinding the teeth at night; INTENSE DESIRE TO PRESS THE GUMS TOGETHER. (PHYTOL.) Difficult dentition. TONGUE BROAD, LARGE, MOIST. Foul, putrid taste. BURNING SENSATION OF TONGUE.

Stomach
Hot, sour belching; nausea and vomiting. Thirst for large quantities of cold water. (BRY.) Vomiting of hot, frothy mucus. Heartburn; gagging or empty retching. Vomiting of milk.

Abdomen
Distended; heat and emptiness. SENSATION OF WEAKNESS OR SINKING. Can lie comfortably only on stomach. Liver region painful, BETTER RUBBING PART. Rumbling and shifting of flatus in ascending colon.

Rectum
Cholera infantum and morbus. Diarrhoea of long standing; EARLY IN MORNING; DURING TEETHING, WITH HOT, GLOWING CHEEKS while being bathed or washed; in hot weather after acid fruits. Morning, painless diarrhoea when not due to venous stasis or intestinal ulceration. Green, watery, FETID, PROFUSE, gushing. PROLAPSE OF RECTUM before or with stool. Constipation; clay-colored, hard, dry, difficult. Constipation alternating with diarrhoea. (ANT. CRUD.) Internal and external piles.

Female
Pain in uterus and RIGHT OVARY, WITH SHIFTING NOISES ALONG ASCENDING COLON. Suppressed menses, with pelvic tenesmus. PROLAPSED UTERI, especially after parturition. Haemorrhoids, with prolapsus ani during pregnancy. Prolapsus from overlifting or straining; during pregnancy.

Extremities
Pain between shoulders, under right scapula, in loins and lumbar region. Pain in right inguinal region; shoots down inner thigh to knees. Paralytic weakness on left side.

Fever
Chill at 7 a. m., with pain in hypochondria, and knees, ankles, wrists. GREAT LOQUACITY during fever. Profuse sweat.

Modalities
Worse, in early morning, in hot weather, during dentition.

Relationship
Compare: MANDRAGORA-also called mandrake-(must not be confounded with PODOPH. Great desire for sleep; exaggeration of sounds and enlarged vision. Bowels inactive; stools large, white and hard). ALOE; CHELID.; MERC; NUX; SULPH. PRUNELLA-Self-heal-(Colitis).

Dose
Tincture to sixth potency. The 200th and 1000th seem to do good work in cholera infantum, when indicated.

Phytolacca is a homeopathic remedy used for the natural treatment of:

• mastitis
• breast inflammation
• breastfeeding problems such as insufficient milk
•  tonsillitis
• pharyngitis
• breast abscesses
• painful nipples
• sore, cracked nipples

From Boericke:

Poke-root) Aching, soreness, restlessness, prostration, are general symptoms guiding to Phytolacca. Pre-eminently a glandular remedy. Glandular swellings with heat and inflammation. Has a powerful effect on fibrous and osseous tissues; fasciae and muscle sheaths; acts on scar tissue. Syphilitic bone pains; chronic rheumatism. Sore throat, quinsy, and diphtheria. Tetanus and opisthotonos. Decrease of weight. Retarded dentition.

Mind
Loss of personal delicacy, disregard of surrounding objects. Indifferent to life.

Head
Vertigo on rising. Brain feels sore. Pain from frontal region backward. Pressure in temples and over eyes. Rheumatism of scalp; pains come on every time it rains. Scaly eruption on scalp.

Eyes
SMARTING. Feeling of sand under lids. Tarsal edges feel hot. Fistula lachrymalis. (FLUOR. AC.) ABUNDANT LACHRYMATION, HOT.

Nose
Coryza; flow of mucus from ONE NOSTRIL AND FROM POSTERIOR NARES.

Mouth
Teething children with irresistible desire TO BITE THE TEETH TOGETHER. Teeth clenched; lower lip drawn down; lips everted; jaws firmly set; chin drawn down on sternum. Tongue RED TIP, feels rough and scalded; bleeding from mouth; blisters on side. Mapped, indented, fissured, with yellow patch down center. Much stringy saliva. Throat. DARK RED OR BLUISH RED. Much pain at root of tongue; soft palate and tonsils swollen. Sensation of a lump in throat. (BELL.; LACH.) THROAT FEELS ROUGH, NARROW, HOT. TONSILS SWOLLEN, especially right; dark-red appearance. SHOOTING PAIN INTO EARS ON SWALLOWING. Pseudo-membranous exudation, grayish white; thick, tenacious yellowish mucus, difficult to dislodge. CANNOT SWALLOW ANYTHING HOT. (LACH.) Tension and pressure in parotid gland. Ulcerated sore throat and diphtheria; THROAT FEELS VERY HOI; PAIN AT ROOT OF TONGUE EXTENDING TO EAR. Uvula large, dropsical- QUINSY; TONSILS AND FAUCES SWOLLEN, with burning pain; can not swallow even water. MUMPS. FOLLICULAR PHARYNGITIS.

Abdomen
Sore spot in right hypochondrium. Rheumatism of abdominal muscles. Colic at navel. Burning griping pains. Bruised feeling through epigastrium and abdomen. Constipation of the aged and those with weak heart. Bleeding from rectum. Urine. Scanty, suppressed, WITH PAIN IN KIDNEY REGION. Nephritis.

Female
Mastitis; MAMMSE HARD AND VERY SENSITIVE. Tumors of the breasts with enlarged axillary glands. Cancer of breast. Breast is hard, painful and of purple hue. Mammary abscess. When child nurses, PAIN GOES FROM NIPPLE ALL OVER BODY. Cracks and small ulcers about nipples. Irritable breasts, before and during menses. Galactorrhoea. (CALC) Menses too copious and frequent. Ovarian neuralgia of right side.

Male
Painful induration of testicles. SHOOTING ALONG PERINEUM TO PENIS.

Heart
Feeling as if heart leaped into throat. (POD.) Shock of pain in cardiac region alternating with pain in right arm.

Respiratory
Aphonia. Difficult breathing; dry hacking, tickling cough; worse at night. (MENTHA; BELLAD.) Aching pains in chest, through mid-sternum; with cough. Rheumatism of lower intercostals.

Back
Aching pains in lumbar region; pains streaking up and down spine into sacrum. Weakness and dull pain in region of kidneys. Back stiff, especially in morning on rising and during damp weather.

Extremities
Shooting pain in right shoulder, with stiffness and inability to raise arm. (see HEART.) Rheumatic pains; worse in morning. PAINS FLY LIKE ELECTRIC SHOCKS, shooting, lancinating, shifting rapidly. (PULS.; KALI BICH.) Pain in under side of thighs. Syphilitic sciatica. ACHING OF HEELS; relieved by elevating feet. Pains like shocks. Pain in legs, patient dreads to get up. Feet puffed; pain in ankles and feet. Neuralgia in toes.

Fever
High fever, alternating with chilliness and great prostration.

Skin
Itches, becomes dry, shrunken, pale. Papular and pustular lesions. Most useful in early stages of cutaneous diseases. DISPOSITION TO BOILS, and when sloughing occurs. Squamous eruptions. Syphilitic eruptions. Swelling and induration of glands. VENEREAL BUBOES. Scarlatina-like rash. Warts and moles.

Modalities
WORSE, sensitive to electric changes. Effects of a wetting, when it RAINS, exposure to DAMP, cold weather, night, exposure, motion, right side. BETTER, warmth, dry weather, rest.

Relationship
Compare: Tincture of PHYTOLACCA BERRY (sore throats and in the treatment of obesity); BRY.; RHUS; KALI HYD.; MERC; SANG.; ARUM TRIPH. Inimical: MERCUR. Antidotes: Milk and salt; BELLAD.; MEZER.

Dose
Tincture, to third potency. Externally for mastitis.